THE physician was to obtain dramatic results with a new type of treatment for multiple sclerosis or multiple sclerosis, which affects about 2.5 million people worldwide. In an initial study, Dr. Paolo Zamboni took 65 patients with relapsing-remitting MS, performed a simple operation to unlock the restricted blood flow out of the brain – and two years after surgery, 73% of patients had no symptoms. thinking of Dr. Zamboni could turn the current understanding of MS on its head, and offer many sufferers a complete cure.


Multiple sclerosis or MS, has been considered as a sentence of life debilitating nerve degeneration. More common in women, the disease affects about 2.5 million people worldwide, causing physical and mental disabilities that can gradually destroy the quality of life of the patient.

It is generally accepted that there is no cure for MS, only treatments that relieve the symptoms – but a new way of looking at the disease, opened the door to a simple treatment that is causing dramatic improvements in a small sample of patients.

Italian Dr. Paolo Zamboni presented the idea that many types of MS are actually caused by a blockage of the pathways which remove excess iron from the brain – and simply wiping a pair of large veins to reopen the flow of blood, the root cause of the disease can be eliminated.

Dr. Zamboni’s revelations came as part of a very personal mission – to heal his wife when she began a downward spiral after diagnosis. Reading everything I could on the subject, Dr. Zamboni found a number of secular sources citing excess iron as a possible cause of MS. It happened to fit with some research he was doing previously on an iron buildup can damage blood vessels in the legs – can be an accumulation of iron was somehow damage the blood vessels in the brain?

He immediately took to the ultrasound machine to see if the idea had some merit – and made a startling discovery. Over 90% of people with MS have some sort of malformation or blockage in the veins that drain blood from the brain. Including, as it turned out, his wife.

He formed a hypothesis about how this could lead to MS: iron accumulates in the brain, blocking and damaging these crucial blood vessels. As the burst vessels, which allow both the iron itself, and blood immune cells to cross the blood-brain barrier in cerebral spinal fluid. Once immune cells have direct access to the immune system, they begin to attack the myelin sheath of the brain nerves – multiple sclerosis develops.

He named the chronic cerebrospinal venous insufficiency problem, or CCSVI.

Zamboni immediately scheduled his wife for a simple operation to unblock the veins – a catheter was passed through the blood vessels in the groin area, all the way to the affected area and then a small balloon was inflated to clear the blockage. It is a standard and relatively free operation of risk – and the results were immediate. In the three years since the surgery, Dr. Zamboni’s wife was not an attack.

Extending their study, Dr. Zamboni, then tried the same operation on a group of 65 ms-sufferers, identifying blood drain blockages in the brain and release them – and more than 73% of patients are completely free of symptoms MS two years after the operation.

In some cases, a balloon is not sufficient to completely open the line channel, which collapses so much so that the balloon is removed, or some time later. In these cases, a metal stent can easily be used, which stays in place permanently maintaining the vein open.

luck finding of Dr. Zamboni is still to be accepted by the medical community, which has traditionally been slow to accept revolutionary ideas. Still, most agree that, although more studies are needed before this is seen as a cure for MS, the results so far have been very positive.

Of course, support groups for MS sufferers are buzzing with the news that a simple operation could free patients that they have always said would be an affliction lifelong, and more studies are being conducted by researchers from around the world hoping to confirm the link between MS and CCSVI, and opens the door for treatment to become available for patients worldwide.

It is certainly a very exciting discovery for multiple sclerosis patients, since it is possible full cure, as opposed to a treatment course of symptoms. We wish Dr. Zamboni and the various teams look more to this problem the best of luck.

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